01 · Investor & Catalyst Briefing · Preclinical Stage

A low-dose psilocybin capsule, designed to be taken at home

Xycota is developing a low-dose oral treatment intended for use at home. If clinical studies establish safety and benefit, this approach could reduce the practical burden of prolonged supervised psychedelic sessions.

Preclinical. Human efficacy and suitability for at-home use remain unestablished.
Signed · Not Closed BioAdaptives, Inc. (OTCQB: BDPT) Definitive Agreement

On October 29, 2026, BioAdaptives, Inc. and Xycota Biosciences, LLC entered into a definitive acquisition agreement, reported on SEC Form 8-K filed November 4, 2026 (subject to customary closing conditions).

Institutional Briefing Film 3:20 · Investor Briefing

A three-minute investor briefing covering the 2026 rat TrkB finding, the repeated-dose blinding question, and the planned 28-day mild PTSD study.

PDF · 15 Slides Investor Mini-Deck: Precision CNS Therapeutics

02 · Delivery Model Comparison · Proposed Preclinical Design Goal

A different treatment model, if the science translates.

Comparing supervised clinic administration with Xycota’s proposed outpatient design goal. Xycota’s candidates are preclinical; clinical safety, blinding, and efficacy in humans have not yet been established.

Conventional Paradigm

Supervised Psychedelic Treatment

  • Setting Clinic setting
  • Time Commitment Scheduled multi-hour attendance
  • Perceptual Profile Prolonged supervised psychedelic dosing
Proposed / Preclinical Design Goal

Xycota’s Proposed Approach

  • Formulation Standardized oral capsule
  • Intended Setting Intended at-home outpatient use
  • Dosing Design Goal Sub-perceptual dose designed to avoid noticeable psychedelic effects

03 · Investigational Pipeline · All Programs Preclinical

Two preclinical programs targeting synaptic repair

Program & Candidate Indication & Delivery Current Stage (Preclinical) Next Decision Gate
XYCO-02 Lead Asset Mild PTSD
Sub-perceptual oral psilocybin capsule
Preclinical
cGMP & CTA dossier with KGK Science
Canadian CTA & Phase 1 PK/PD waiver submission
XYCO-01 Follow-On Frontotemporal Dementia (FTD)
Neural-exosome psilocin
Preclinical
FDA Orphan Drug Designation filed
FDA ODD feedback & gated head-to-head FTD animal study
+ What “sub-perceptual” means & clinical dosing design goal

What “sub-perceptual” means: Sub-perceptual describes the preclinical design goal for XYCO-02: low-dose oral psilocybin formulated to remain below the threshold of noticeable psychedelic effects (with a 1.5 mg reference dose evaluated in planning and final clinical dose to be determined). Whether participants with mild PTSD can distinguish XYCO-02 from placebo during repeated 28-day dosing remains an open clinical question.

04 · Published Preclinical Evidence · Observed in Rats

Cognitive rescue in a Fragile X rat model required TrkB signaling, not 5-HT2A activation

Published in Neuropsychopharmacology (July 2026) and co-authored by Xycota CSO Dr. Marvin S. Hausman, MD in Fmr1-Δexon 8 rats.

Experimental Receptor-Blockade Schematic · Fmr1-Δexon 8 Rats DOI: 10.1038/s41386-026-02361-x ↗
01. Low-Dose Psilocybin 0.1 mg/kg Oral Regimen No receptor antagonist added
Pathway State TrkB / mBDNF Active PFC pAKT/AKT normalized
Rat Outcome Memory Restored Wild-type discrimination index
02. + 5-HT2A / 1A Blocker M100907 or WAY-100635 Psychedelic receptor blocked
Pathway State TrkB Unblocked Neurotrophic signaling intact
Rat Outcome Rescue Maintained Not blocked by 5-HT2A/1A
03. + TrkB Antagonist ANA-12 (1.0 mg/kg i.p.) Selective TrkB receptor blockade
Pathway State TrkB Halted BDNF/TrkB cascade blocked
Rat Outcome Rescue Abolished $ p < 0.05 vs. VEH-PSY
Ascone et al., Neuropsychopharmacology (2026) 51(8):1454-1463 · CC BY 4.0
01 · Observed in a Rat Model of Fragile X (Fmr1-Δexon 8)

TrkB required; 5-HT2A blockade did not prevent rescue

Repeated low-dose oral psilocybin restored object-recognition memory and normalized prefrontal cortex mature BDNF/TrkB/pAKT; blocking TrkB (ANA-12) abolished the rescue, while blocking 5-HT2A or 5-HT1A did not.

02 · Human Translation Limitation

Not yet demonstrated in humans or in PTSD

The 2026 study evaluated a genetic rat model of Fragile X Syndrome, not a trauma model or human subjects.

+ Explore the evidence & published figures (Fig. 3 & Fig. 5)

BDNF/TrkB signaling hypothesis: These preclinical findings suggest synaptic repair signaling in rats can proceed through BDNF/TrkB rather than the 5-HT2A receptor associated with acute psychedelic effects.

Full Science page walkthrough →

05 · Decision Timeline & Falsification Criteria

What happens next

Solid bars denote active company preparation; dashed bars denote conditional regulatory review and clinical execution.

XYCO-02 (Mild PTSD) Sequence Legend: Company preparation (solid line) Regulatory decisions (no promised date) Activities dependent on authorization
01
Current Active Step · Company Prep

cGMP Capsule Dossier

Finalize cGMP capsule stability package for XYCO-02 clinical supply with CRO partner KGK Science.

02
Next Step · Company Prep

Canadian CTA Filing

Submit the XYCO-02 Clinical Trial Application and Phase 1 PK/PD waiver request with KGK Science.

03
Regulatory Review · No Promised Date

Health Canada & REB

Health Canada and Research Ethics Board evaluate CTA authorization and Phase 1 PK/PD waiver request.

04
Dependent on Authorization

28-Day Mild PTSD Study

Run 28-day double-blind outpatient study (CAPS-5 + blood BDNF) following regulatory clearance.

Separate Follow-On Branch · XYCO-01 (FTD) FDA Orphan Drug Designation feedback → Gated head-to-head FTD animal study following XYCO-02 clinical initiation
XYCO-01 program details →
+ Proposed 28-day mild PTSD study mechanics (KGK Science, CAPS-5 primary endpoint & supporting blood BDNF readout)

Outpatient trial architecture: Proposed randomized, double-blind, placebo-controlled 28-day at-home regimen of a standardized, sub-perceptual oral psilocybin capsule vs. matched placebo in adults with mild PTSD, conducted with CRO partner KGK Science.

Endpoints: Clinician-Administered PTSD Scale for DSM-5 (CAPS-5) serves as the primary clinical endpoint, paired with serum BDNF in blood as a supporting pharmacodynamic readout (not a surrogate endpoint). Specific sample size, statistical powering, and secondary endpoint hierarchies remain subject to science-team sign-off and Health Canada CTA review.

+ Regulatory precedent, prior NCT05832255 context & financing dependencies

Prior KGK Science & Health Canada context: CRO partner KGK Science previously conducted a Health Canada authorized study of low-dose, sub-perceptual oral psilocybin in adults with Fragile X Syndrome (NCT05832255), sponsored by Nova Mentis Life Science Corp., where Xycota CSO Dr. Marvin S. Hausman, MD previously served as Scientific Director (Nova Mentis has since undergone corporate restructuring and ceased its research operations). That study was open-label, single-arm, enrolled up to 10 participants, and is listed as suspended pending protocol revisions. Xycota does not own or control that dataset.

Material dependencies: Whether prior cGMP low-dose capsule experience and Health Canada outpatient authorization precedent support a Phase 1 PK/PD waiver for XYCO-02 is a decision for Health Canada; no regulatory decision date is promised. Study initiation is conditional on CTA authorization, REB approval, cGMP supply release, and financing close.

Three questions the study must answer

Principal unresolved questions & falsification criteria
Question 01 · Disease Translation

Does a Fragile X rat mechanism translate to human PTSD?

Direct answer: Not yet demonstrated; our 2026 study evaluated object recognition in a genetic rat model of Fragile X Syndrome, and we have not run a rodent fear-extinction or trauma study.

+ Read full scientific context & resolution gate

PTSD involves distinct neural circuitry from Fragile X Syndrome. Our hypothesis that BDNF/TrkB synaptic restoration is indication-agnostic draws on published literature (Peters et al., Science 2010; Moliner et al., 2023), but remains untested in human trauma. Resolution requires CAPS-5 symptom separation from placebo in the planned XYCO-02 study.

Question 02 · Repeated-Dose Blinding

Does blinding hold with sub-perceptual dosing over 28 days?

Direct answer: Open clinical question; single-dose healthy-volunteer threshold data (Levy-Cooperman et al., 2026) do not establish whether mild PTSD patients remain blinded over 28 days of repeated at-home dosing.

+ Read full scientific context & resolution gate

In macrodose psychedelic trials, functional unblinding exceeds 90% (Muthukumaraswamy et al., 2021). XYCO-02 is formulated to stay below perceptual thresholds, and the planned 28-day outpatient study will prospectively measure blinding integrity alongside CAPS-5 outcomes.

Question 03 · Biomarker Interpretation

Does peripheral blood BDNF reflect central brain repair?

Direct answer: Serum BDNF is a noisy peripheral measure subject to platelet and assay variability; it is a supporting pharmacodynamic readout, not a surrogate endpoint.

+ Read full scientific context & resolution gate

A change in peripheral blood BDNF alone does not establish central synaptic repair. Researchers plan to evaluate blood BDNF strictly alongside primary CAPS-5 clinical scores under standardized collection and pre-specified assay controls.

06 · Responsibility & Governance

Who will execute

Company Leadership & Board Governance Executive Officers, Lab Operations & Institutional Oversight
Dr. Marvin S. Hausman, MD, Chief Scientific Officer & Co-Founder of Xycota Biosciences
Co-Founder & CSO

Dr. Marvin S. Hausman, MD

Chief Scientific Officer & Co-Founder · Xycota

Co-authored the 2026 rat study; former NIH USPHS Surgeon and developer of six FDA-approved NDAs. Full biography →

Brad Listermann, Co-Founder & CEO of Xycota Biosciences
Co-Founder & CEO

Brad Listermann

Co-Founder & CEO · Xycota Biosciences

Directs strategy, IP, and capital formation; inventor with filed patent applications spanning AI and cryptographic systems. Full biography →

Dr. Anthony Smith, PhD, Senior Lab Operations Manager at Xycota Biosciences
Lab Operations

Dr. Anthony Smith, PhD

Senior Lab Operations Manager · Xycota

Leads lab operations and Colorado exosome/liposome formulation; PhD in Molecular Biology (OSU), former President & CSO of EVIO Labs. Full biography →

Lt. Col. Elton Johnson Jr. (Ret.), Incoming Board Director / Advisor
Board & Governance

Lt. Col. Elton Johnson Jr. (Ret.)

Incoming Board Director · AmeriVet Securities

Provides institutional broker-dealer regulatory governance (FINRA Series 24/27/7/53) and 37-year combat veteran oversight. Full biography →

External Academic and CRO Collaborators (Not Xycota Employees) Independent research laboratories & regulatory partners
Associate Professor Viviana Trezza, PhD, Roma Tre University
Academic Collaborator

Prof. Viviana Trezza, PhD

Roma Tre University (Italy)

Senior author of the 2026 rat study establishing TrkB-dependent memory rescue. Full biography →

Dr. Louise Hecker, PhD, Baylor College of Medicine
Academic Collaborator

Dr. Louise Hecker, PhD

Baylor College of Medicine

Senior author of the 2025 npj Aging study on psilocin and cellular survival in aged mice. Full biography →

Andrew Charrette, MSc, Regulatory Advisor at KGK Science
Regulatory Advisor

Andrew Charrette, MSc

KGK Science Inc. (Canada)

Advises on Xycota’s Health Canada CTA and Phase 1 PK/PD waiver submission. Full biography →

07 · Press Releases & Public Announcements

Official press releases and company news

Showing the latest company announcements in a compact scrollable feed. Click any headline or button to open the full press release.

Latest Releases Feed · Scroll for Archive
Public Science & Research · OTCID: BDPT Las Vegas, NV & Sheridan, WY

Former UFC Middleweight Champion to join Xycota Chief Scientific Officer Marvin S. Hausman, M.D., for an upcoming podcast examining repeated head impact, PTSD, and sub-perceptual psilocybin research targeting brain-repair pathways.

Brief:UFC Hall of Famer Michael Bisping is lending his support to spotlight Xycota’s preclinical XYCO-02 low-dose psilocybin program and joining Co-Founder and CSO Marvin S. Hausman, M.D., for an unscripted public science dialogue on concussion, mild traumatic brain injury (mTBI), and mild PTSD.

Official Wire Release ↗
Veterans Day · Community & Resource Hub Sheridan, WY

Guided by 37-year combat veteran Lt. Col. Elton Johnson Jr., U.S. Army (Ret.), and physician-scientist Marvin S. Hausman, M.D., every tool on the hub requires zero login, stays off the record, and can be used directly from a phone.

Brief:Confronting the physical biology of trauma and the stigma keeping 73% of positively screened veterans out of care, Xycota launched a free mobile and web resource suite at xycota.com/ptsd featuring 60-second grounding resets, family talking-point cards, and off-record VSO matching.

Open PTSD Hub (/ptsd) →
Corporate Transaction · OTCID: BDPT ACCESS Newswire

Xycota’s lead program aims to deliver clinical benefit from low-dose psilocybin without hallucinogenic effects, with mild PTSD as its initial target.

Brief:BioAdaptives, Inc. (OTCID: BDPT) signed a definitive agreement dated October 29, 2026 to acquire Xycota Biosciences, LLC as a wholly owned subsidiary operating under Co-Founders Brad Listermann (CEO) and Marvin S. Hausman, M.D. (CSO), subject to closing conditions reported on SEC Form 8-K.

Yahoo Finance / Wire ↗
SEC Filing · Form 8-K · OTCID: BDPT SEC EDGAR

Current Report on Form 8-K (Items 1.01 and 3.02) and Exhibit 10.1 set forth the October 29, 2026 acquisition agreement, governance structure, and milestone-linked note financing terms.

Brief:The filing details the proposed acquisition of Xycota Biosciences as a wholly owned subsidiary of BioAdaptives, Inc., including separate Xycota bank account controls, Economic and Voting Preferred stock terms, and closing conditions through June 30, 2027.

SEC EDGAR Form 8-K ↗

08 · Public Filings & Confidential Diligence

Investor resources and diligence access

Immediate access to public SEC filings and peer-reviewed publications on the left, or NDA-gated institutional data room access on the right.

Route 02 · NDA Required

Confidential Institutional Data Room

Qualified institutional investors and strategic partners may request access to confidential CMC, Health Canada CTA, and FDA Orphan Drug dossiers following mutual NDA execution.